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SpectraComp® Controls are precision engineered single stain cell mimics designed to optimize spectral unmixing and compensation in multiparameter flow cytometry workflows. These controls mimic the staining performance of real cells and provide positive and negative fluorescence peaks after staining with fluorescently conjugated antibodies. Each control captures antibodies from mouse, rat and hamster sources, supporting broad panel compatibility and diverse fluorophore selections. With high fluorescence response and cell like autofluorescence, SpectraComp delivers superior signal to noise resolution and reduces errors associated with spectral overlap. Its consistent fluorescence intensity and physiologically relevant scatter characteristics outperform traditional polystyrene based beads while preserving the behavior of cell based controls. SpectraComp is suitable for spectral unmixing or conventional compensation and is supplied as a single vial containing both positive and negative capture mimics for streamlined workflows. These controls require no special handling or safety precautions and have been validated on analytical flow cytometers for dependable performance in daily QC, assay development and high parameter panel design. Benefits: Unparalleled high fluorescence response (greater than 10e5 MFI on most bright fluorochrome) Conveniently works with multiple species of antibodies: mouse, rat, and hamster Exceptional performance in spectral analysis and unmixing Compatible with violet and UV fluorochromes Cell-like autofluorescence for superior signal-to-noise resolution Resources: SpectraComp® Application Note Technical Data Sheet Safety Data Sheet Certificate of Analysis Poster: Spectral Cytometry Reference Controls: The Search for the Perfect Particle Publication: Jensen, HA, Kim, J. iCoreDrop: A robust immune monitoring spectral cytometry assay with six open channels for biomarker flexibility. Cytometry. 2023; 103(5): 405–418. https://doi.org/10.1002/cyto.a.24708

SpectraComp® XT Controls are precision engineered single stain cell mimics designed to optimize spectral unmixing and compensation in multiparameter flow cytometry workflows. These controls mimic the staining performance of real cells and provide clear positive and negative fluorescence peaks after staining with fluorescently conjugated antibodies.As with all SpectraComp Controls, SpectraComp XT delivers high fluorescence response and cell-like autofluorescence to provide superior signal to noise resolution and reduce errors associated with spectral overlap. The consistent fluorescence intensity and physiologically relevant scatter characteristics of SpectraComp Controls outperform traditional polystyrene based beads and support reliable unmixing across instruments and platforms. SpectraComp XT expands species compatibility by capturing antibodies from mouse, rat, hamster, rabbit and human sources, supporting broad panel design and diverse fluorophore selections. Compatible with violet, UV and tandem dyes, these controls are supplied as a combined positive and negative population for streamlined workflow integration.These controls require no special handling or safety precautions and have been validated on analytical flow cytometers for dependable performance in daily QC, assay development and high parameter panel design. Benefits: Unparalleled high fluorescence response (greater than 10e5 MFI on most bright fluorochrome) Conveniently works with multiple species of antibodies: mouse, rat, hamster, rabbit, and human Exceptional performance for unmixing/compensation across instrument platforms Compatible with violet, UV fluorochrome, and tandem dyes Consistent fluorescence signals for reliable performance Designed to support easier analysis workflows with their cell-like attributes (size, scatter, and autofluorescence) Combined positive and negative populations for ease-of-use Resources: Technical Data Sheet Safety Data Sheet Certificate of Analysis Poster: Spectral Cytometry Reference Controls: The Search for the Perfect Particle Publication: Jensen, HA, Kim, J. iCoreDrop: A robust immune monitoring spectral cytometry assay with six open channels for biomarker flexibility. Cytometry. 2023; 103(5): 405–418. https://doi.org/10.1002/cyto.a.24708

SpectraComp® eGFP Controls are precision engineered multi level fluorescent cell mimics designed to support accurate unmixing, compensation and calibration of GFP signals in multiparameter flow cytometry workflows. These controls present eGFP protein on the particle surface and provide negative, low, medium and high fluorescence populations that mimic the performance of eGFP expressing cells. Each positive population contains a defined number of eGFP molecules, generating distinct fluorescence intensity levels for reliable benchmarking and reference signal generation. With consistent fluorescence intensity, cell-like autofluorescence and the high performance characteristics shared across all SpectraComp Controls, SpectraComp eGFP delivers dependable signal resolution and reduces errors associated with spectral overlap. The kit includes four liquid dropper vials containing separate negative, low, medium and high populations, supporting flexible experimental setup and streamlined workflow integration. These controls are suitable for spectral unmixing, conventional compensation, fluorescence calibration and assessment of transfection efficiency. SpectraComp eGFP requires no special handling or safety precautions and has been validated on analytical flow cytometers for dependable performance in daily QC, assay development and high parameter panel design. Unit Size: 25 tests of each populationPackaging: separate neg, low, med, and high populationsProduct format: 4 liquid dropper vialsApplication: Unmixing, compensation, calibration, or transfection efficiency control Benefits: State-of-the-art controls designed using actual eGFP protein (excitation peak at 488 nm and max emission at 507 nm) Three mean fluorescence intensity levels (low, medium, and high) Consistent fluorescence signals for reliable performance Cell-like autofluorescence for workflow efficiency Resources: Technical Data Sheet Safety Data Sheet Certificate of Analysis

SpectraComp® Flex Controls are precision engineered single stain cell mimics designed to optimize compensation and support accurate spectral unmixing in multiparameter flow cytometry workflows. These controls mimic the staining performance of real cells and provide a clear positive fluorescence histogram after staining with fluorescently conjugated antibodies. Each control captures antibodies from mouse, rat and hamster sources, supporting broad panel compatibility and diverse fluorophore selections. With unparalleled high fluorescence response and cell-like autofluorescence, SpectraComp Flex Controls deliver superior signal to noise resolution and reduces errors associated with spectral overlap. The consistent fluorescence intensity and physiologically relevant scatter characteristics of all SpectraComp Controls outperform traditional polystyrene based beads and support dependable compensation across instruments and platforms. To further support flexible experiment setup, SpectraComp Flex is supplied in separate positive and negative vials. These controls require no special handling or safety precautions and have been validated on analytical flow cytometers for reliable performance in daily QC, assay development and high parameter panel design. Benefits: Unparalleled high fluorescence response (greater than 10e5 MFI on most bright fluorochromes) Conveniently works with multiple species of antibodies: mouse, rat, and hamster Exceptional performance for compensation across instrument platforms Compatible with violet, UV fluorochrome, and tandem dyes Cell-like autofluorescence for superior signal-to-noise resolution Resources: Technical Data Sheet Safety Data Sheet Certificate of Analysis Poster: Spectral Cytometry Reference Controls: The Search for the Perfect Particle Publication: Jensen, HA, Kim, J. iCoreDrop: A robust immune monitoring spectral cytometry assay with six open channels for biomarker flexibility. Cytometry. 2023; 103(5): 405–418. https://doi.org/10.1002/cyto.a.24708

SpectraComp® Flex XT Controls are precision engineered single stain cell mimics designed to optimize compensation and support accurate spectral unmixing in multiparameter flow cytometry workflows. These controls mimic the staining performance of real cells and provide a clear positive fluorescence histogram after staining with fluorescently conjugated antibodies. With high fluorescence response and cell-like autofluorescence, SpectraComp Flex XT delivers the superior signal to noise resolution characteristic of all SpectraComp Controls. The consistent fluorescence intensity and physiologically relevant scatter characteristics of these controls outperform traditional polystyrene based beads and support reliable compensation and unmixing across instruments and platforms. Compatible with violet, UV and tandem dyes, SpectraComp Flex XT is supplied in separate positive and negative vials to maximize the number of tests and streamline workflow integration. Flex XT expands species compatibility by capturing antibodies from mouse, rat, hamster, rabbit and human sources, supporting broad panel design and diverse fluorophore selections. These controls require no special handling or safety precautions and have been validated on analytical flow cytometers for dependable performance in daily QC, assay development and high parameter panel design. Benefits: Unparalleled high fluorescence response (greater than 10e5 MFI on most bright fluorochromes) Conveniently works with multiple species of antibodies: mouse, rat, hamster, rabbit, and human Exceptional performance for compensation/unmixing across instrument platforms Compatible with violet, UV fluorochrome, and tandem dyes Consistent fluorescence signals for reliable performance Designed to support easier analysis workflows with their cell-like attributes (size, scatter, and autofluorescence) Separate positive and negative vials for the maximum number of tests Resources: Technical Data Sheet Safety Data Sheet Certificate of Analysis Poster: Spectral Cytometry Reference Controls: The Search for the Perfect Particle Publication: Jensen, HA, Kim, J. iCoreDrop: A robust immune monitoring spectral cytometry assay with six open channels for biomarker flexibility. Cytometry. 2023; 103(5): 405–418. https://doi.org/10.1002/cyto.a.24708

SpectraComp® Flex Multipeak Controls are precision engineered hydrogel based single stain controls designed to support accurate compensation, spectral unmixing and fluorescence standardization in multiparameter flow cytometry workflows. These hydrogels capture antibodies from mouse, rat, hamster and rabbit sources and provide three defined levels of antibody binding — negative, medium and high — enabling multi level reference signals that mimic the fluorescence spectra of stained cells across multiple antigen density levels. With the consistent fluorescence intensity, cell-like autofluorescence and broad antibody species compatibility characteristic of all SpectraComp Controls, SpectraComp Flex Multipeak outperforms traditional bead based tools and reduces errors associated with spectral overlap. Each kit includes a negative bottle containing a 100% negative population and a positive bottle containing a 50% high and 50% medium population. After staining with fluorescently conjugated antibodies, the hydrogels yield a fluorescence histogram with two positive peaks and one negative peak, supporting clear fluorophore performance assessment and reliable single stain reference signals for compensation and unmixing. These controls require no special handling or safety precautions and have been validated on analytical flow cytometers for dependable performance in daily QC and long term panel design. The product contains: Hydrogels with 3 levels of antibody capture: Negative Medium High Each kit comes with 2 dropper bottles (liquid) Negative Bottle: 100% negative population 100,000 hydrogels per drop Positive Bottle: 50% High / 50% Medium 100,000 hydrogels per drop (50,000 of each population) SpectraComp® Flex Multipeak can be used for compensation or spectral unmixing or as an instrument standardization control for fluorescence. Resources Technical Data Sheet Safety Data Sheet Certificate of Analysis

ViaComp® viability controls are precision engineered 2‑in‑1 synthetic cell mimics designed to replicate the staining behavior of real cells for both DNA‑intercalating dyes (such as 7‑AAD and PI) and amine‑reactive viability dyes. Each drop contains a pre‑mixed suspension of positive and negative control particles that generate clear, well‑separated fluorescence peaks, enabling accurate identification of live and dead cell populations. Unlike biological materials, ViaComp® provides exceptionally bright positive signals with no non‑specific binding in the negative population, ensuring consistent and reproducible performance across operators and instruments. The ready‑to‑use dropper format streamlines workflow integration and eliminates the variability, fragility and preparation requirements associated with cell‑based controls. ViaComp® has been verified and validated on analytical flow cytometers and is intended for research use only. Resources: ViaComp® Application Note Technical Data Sheet Safety Data Sheet Certificate of Analysis

Convenient and reliable controls to measure cell health. ViaComp® Flex viability controls are advanced 2-in-1 beads that bind to DNA intercalating dyes (7AAD, PI) and amine-reactive viability dyes to simulate the staining of cells.This product is intended as a process and assay control to match the viability staining of real cells. Packaged in two bottles with the positive and negative controls in separate vials. Features: Compatible with both DNA intercalating dyes (7AAD, PI) and amine-reactive viability dyes Superior resolution of negative and positive peaks Measure toxicity with confidence Workflow flexibility for toxicity study with separated positive and negative controls Resources: Technical Data Sheet Safety Data Sheet Certificate of Analysis

TBNK Mimic™is a lyophilized cell mimic designed for reliable performance checks and normalization controls in immunophenotyping and flow cytometry workflows. These controls feature T cell, B cell and NK cell markers with scatter characteristics that closely resemble lymphocyte, monocyte and granulocyte populations. Each control includes well‑defined populations that reflect physiologically relevant antigen densities: CD4+ T cells (CD45+, CD3+, CD4+), CD8+ T cells (CD45+, CD3+, CD8+), B cells (CD45+, CD3−, CD19+), NK cells (CD45+, CD3−, CD16/56+), classical monocytes (CD45+, CD14+) and granulocytes (CD45+, CD16+). Their engineered FSC and SSC profiles closely resemble the scatter characteristics of human peripheral blood populations, enabling confident population discrimination and gating across diverse cytometry platforms. Offering superior lot‑to‑lot reproducibility and exceptional long‑term stability, TBNK Mimics outperform fresh primary cells, frozen preparations and conventional lyophilized products. With no biohazard material and no special handling or disposal requirements, they provide a dependable alternative to biologically derived controls while maintaining consistent antigen presentation and physiologically relevant scatter characteristics. This combination of stability, reproducibility and well‑defined population structure supports accurate gating, antibody performance assessment and instrument verification across daily QC, assay validation and longitudinal performance monitoring. The lyophilized format ensures consistent reconstitution and extended shelf life, making TBNK Mimics suitable for multi‑site standardization, training and long‑term assay harmonization. Resources: Technical Data Sheet Certificate of Analysis

StimCytes™ CD19 are precision engineered synthetic cell mimics designed to support CAR‑T potency assessment through targeted CD19 specific activation, cytokine release and biomarker driven assay development. Each kit enables baseline, enhanced and negative activation profiles of CD19 directed CAR‑T cells during antigen engagement. Unlike cell controls, StimCytes™CD19 provides consistent antigen expression and reproducible activation characteristics that remove the variability associated with donor derived materials. These lyophilized synthetic cells feature selected biomarkers that support stable potency evaluation and streamlined assay optimization across experiments and platforms. The kit includes a high activation mimic with enhancers, a baseline activation mimic and a non activating negative control to establish clear functional benchmarks. StimCytes™CD19 are intended for research use only and are not suitable for diagnostic or therapeutic procedures. These products are safe to use in any environment, contain no biohazardous material and require no special disposal. (FKA: TruCytes™ Potency BCMA) More information: Poster:Cell Mimics as High Precision Controls For CGT Analytics and Potency Assays Application Note:Cell Mimics as a Robust Quality Control Platform for Reliable CAR-T Potency Assays ResourcesTechnical Data Sheet

StimCytes™ BCMA are precision engineered synthetic cell mimics designed to support CAR‑T potency assessment through targeted BCMA specific activation, cytokine release and biomarker driven assay development. Each kit enables baseline, enhanced and negative activation profiles of BCMA directed CAR‑T cells during antigen engagement. Unlike cell controls, StimCytes™ BCMA provides consistent antigen expression and reproducible activation characteristics that remove the variability associated with donor derived materials. These lyophilized synthetic cells feature selected biomarkers that support stable potency evaluation and streamlined assay optimization across experiments and platforms. The kit includes a baseline activation mimic, an enhanced activation mimic with enhancers and a non activating negative control to establish clear functional benchmarks. The StimCytes™ BCMA product is part of an early release program with specifications subject to refinement as additional validation is completed. These products are intended for research use only and are not suitable for diagnostic or therapeutic procedures. They are safe to use in any environment, contain no biohazardous material and require no special disposal. ResourcesTechnical Data Sheet

QuantCytes™ CD19 quantitation controls are precision engineered lyophilized cell mimics designed to quantify CD19 molecules per cell and support consistent expression benchmarking across research and development workflows. These synthetic cells feature the CD19 biomarker with scatter properties resembling human lymphocytes, enabling realistic assay performance and reliable calibration. Each kit provides four defined populations representing negative, low, medium and high CD19 expression levels. Each positive population contains a known number of CD19 molecules, generating distinct fluorescence intensities and antigen density levels for accurate quantification. Using a PE or APC conjugated CD19 antibody, these controls allow direct measurement of antibody binding capacity without requiring knowledge of fluorophore molecules per antibody. Incorporating the measured intensities into the provided Antigen Density Calculator enables generation of a signal to antigen standard curve that can be used to quantify antigen densities on cell targets with the same instrumentation and antibody. As with all QuantCytes™ products, QuantCytes™ CD19 quantitation controls are safe to use in any environment, contain no biohazardous material and require no special disposal. ResourcesTechnical Data Sheet Certificate of Analysis Antigen Density Calculator Poster: Enhancing Immunophenotyping Standardization in Clinical Labs with Quantitative BCMA or CD19 Cell Mimics